CSSPrefixer

You hate writing vendor prefixes for all browsers? Just let CSSPrefixer do it for you!

See it in action:

keep your styles clean

Installation

easy_install cssutils (or pip install cssutils if you have pip)

Usage:

From console

cssprefixer my1.css my2.css --minify > result.css

From Python

import cssprefixer
      cssprefixer.process(open('my.css').read(), debug=False, minify=True)
      

With Django or Flask

P.S.

Looking for a client-side solution? Try -prefix-free by Lea Verou.

What's better — client- or server-side — depends on your project. Basically, JavaScript-dependent apps with lots of CSS3 go with a JS solution such as -prefix-free, sites go with CSSPrefixer. But it's harder than that, really.